Health Benefits
Anti-inflammatory Potential
Previous research has demonstrated anti-inflammatory activity by abalone extracts using laboratory-based cell assays (in vitro). In these assays mouse monocytes (RAW264) are stimulated with bacterial lipopolysaccharide to produce the pro-inflammatory mediator nitric oxide (NO)1, therefore a decrease in NO production by LPS stimulated RAW264 cells is indicative of anti-inflammatory activity. Treatment with 96-375 μg/mL abalone extracts reduced NO production (Figure 3) similarly to 100 μM Quercetin used as a positive control (data not shown) indicating anti-inflammatory activity. Treatment with lower concentrations (12-48 μg/mL) of abalone extract was not as effective as Quercetin treatment (and is denoted by*).
ABALONE EXTRACT
In an animal model (in vivo) of rheumatoid arthritis, prophylactic and therapeutic administration of an abalone extract alleviated swelling and deformity and significantly lowered the mean clinical score (compared to untreated control mice with significance denoted by * in Figure 4)2. Taken together, in vitro and in vivo results suggest abalone extracts have anti-inflammatory activity that may prevent or alleviate the symptoms of arthritis.
References
1. Suleria, H.A.R. Addepalli, R. Masci, P. et al. 2017. In vitro anti-inflammatory activities of blacklip abalone (Haliotis rubra) in RAW 264.7 macrophages. Food and Agricultural Immunology, 28:4, 711-724, DOI:10.1080/09540105.2017.1310186
2. Osborne, S. WO 2017/124149. Blacklip